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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Fig. 6

HMGCS1 reversed the oncogenic effects of ACSS2 in vitro. A–D Overexpression of ACSS2 upregulated the expression of HMGCS1 and knockdown of ACSS2 downregulated the expression of HMGCS1 by qRT-PCR and WB. E Co-IP demonstrated ACSS2 and HMGCS1 interaction. F, G CCK-8 assay indicated that overexpression of HMGCS1 reversed the tumor-suppressive effect of ACSS2 knocked down. H, I The colony formation suggested that overexpression of HMGCS1 reversed the tumor-suppressive effect of ACSS2 knocked down. J, K EdU assay indicated that overexpression of HMGCS1 reversed the DNA synthesis suppressed effect of ACSS2 knocked down. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Journal of Translational Medicine

ISSN: 1479-5876

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