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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Fig. 4

ACSS2 regulated lipid metabolism reprogramming in pNENs cells. A Increased lipid droplets after overexpression of ACSS2. B, C Knockdown of ACSS2 and ACSS2i treatment reduced lipid droplets. D, E Overexpression of ACSS2 increased triglyceride and total cholesterol, knockdown of ACSS2 reduced triglyceride and total cholesterol. F Overexpression of ACSS2 reduced free fatty acid and knockdown of ACSS2 increased free fatty acid. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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