Table 1 Clinical and pathological staging, grading, and observations in rhesus with naturally occurring CRC
ID | Sex | Age at | Diagnosis by | FOB | Available imaging | T | N | M | Grade | Fibrosis | Subtype | Localization / spread | Comorbidities | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arrival | Death | |||||||||||||
CRC_1 | m | 21.0 | 21.7 | Biopsy | pos | US & CT & FDG-PET | 3 | 1 | 0 | 2 | pos | AdenoCa | Ileocecal junction, cecocolic junction, metastasis: tumor-assoc. LN | Weight loss, anemia, hypoproteinemia |
CRC_2 | f | 12.3 | n.A | Biopsy | pos | US & CT | 3 | 0 | 0 | 2 | pos | AdenoCa | Ileocecal junction, cecocolic junction | st.p.tumor resection, typhlocolitis |
CRC_3 | m | 19.6 | 20.8 | Necropsy | pos | US & CT | 3 | 0 | 0 | 2 | pos | AdenoCa | Cecocolic junction | Weight loss, azotemia |
CRC_4 | f | 18.9 | 20.0 | Biopsy | pos | US & CT | 4 | 0 | 0 | 1 | pos | AdenoCa | Ileocecal junction | weight loss, anemia, arthritis, thrombocytosis, lipoma |
CRC_5 | f | 22.1 | 22.9 | Biopsy | pos | US & CT | 4 | 0 | 1 | 1 | pos | AdenoCa | Ileocecal junction, spread to mesenteric tissue/jejunum, miliary omental carcinomatosis metastasis: spleen, uterus, ovary | weight loss, anemia, umbilical hernia |
CRC_6 | f | 22.8 | 23.5 | Biopsy | n.A | US & CT | 3 | 1 | 1 | 1 | pos | AdenoCa | Ileocecal junction (resected) tumor recurrence inflicting ovary, distant metastasis to adrenal gland, spine, extensive infiltration of vertebral body L2 | st.p.tumor resection, hind limb paresis |
CRC_7 | m | 22.5 | 23.6 | Biopsy | pos | US & CT & FDG-PET | 3 | 1 | 0 | 1 | pos | Mucinous AdenoCa | Ileocecal junction metastasis: LN | Hypoalbuminemia |
CRC_8 | m | 18.5 | 19.6 | Biopsy | pos | US & CT & FDG-PET | 3 | 1 | 0 | 1 | pos | Mucinous AdenoCa | Ileocecal junction metastasis: LN | Anemia, hypoalbuminemia |
CRC_9 | f | 18.5 | 18.8 | Biopsy | pos | US & CT | 3 | 1 | 1 | 1 | pos | Mixed (mucinous/ AdenoCa/solid) | Ileocecal junction metastasis: LN, lung, omentum | Weight loss, anemia, hypoproteinemia |
CRC_10 | f | 22.4 | 22.7 | Biopsy | pos | US & CT | 4 | 0 | 0 | 1 | pos | AdenoCa | Ileocecal junction, local spread to mesentery | Acute gastric bloat, hypochromic-microcytic anemia, hypoalbuminemia, hypoproteinemia, thrombocytosis |
CRC_11 | f | 17.9 | 19.9 | Biopsy | n.A | US & CT | 4 | 1 | 1 | 1 | pos | AdenoCa | Ileocecal junction, metastasis: lung, liver, uterus, ax.LN, spleen, stomach, adrenal gland, pancreas, urinary bladder, ovary, omentum, bone (rib) | Weight loss, anemia, hypoalbuminemia |
CRC_12 | f | 25.6 | 26.2 | Necropsy | neg | US & CT & contrast-enhanced CT | 3 | 1 | 0 | 1 | pos | AdenoCa | Ileocecal junction, lymphatic invasion | Abdominal distensions, cecal obstruction, arthritis |
CRC_13 | m | 23.5 | 23.8 | Necropsy | n.A | US & CT | 3 | 0 | 0 | 1 | pos | AdenoCa | Ileocecal junction | Urinary retention due to chronic bladder atony, weight loss, arthritis, scoliosis, 0.25 × 0.1mm Meningioma |
CRC_14 | f | 23.6 | 24.9 | Biopsy | pos | US & CT & contrast-enhanced CT | 2 | 0 | 0 | 1 | neg | AdenoCa | Ileocecal junction | Hypoalbuminemia |
CRC_15 | f | 16.5 | 17.8 | Biopsy | pos | US & CT & contrast-enhanced CT | 2 | 0 | 0 | 1 | pos | AdenoCa | Ileocecal junction | Acute post-surgery complications, hypoalbuminemia |
CRC_16 | f | 18.1 | 18.2 | Necropsy | n.A | n.A | 3 | 0 | 0 | 1 | pos | AdenoCa | Ileocecal junction | Acute partial cecal obstruction, cachexia |
CRC_17 | f | 21.8 | 23.6 | Necropsy | pos | US & CT | 3 | 0 | 0 | 2 | pos | Mucinous AdenoCa | Cecocolic junction | Anemia |
CRC_18 | f | 22.1 | 22.6 | Necropsy | pos | US & CT | 2 | 0 | 0 | 1 | pos | AdenoCa | Ileocecal junction | Anemia |
CRC_19 | f | 24.3 | 24.8 | Biopsy | pos | US & CT & FDG-PET | 3 | 0 | 0 | 1 | pos | AdenoCa | Ileocecal junction, proximal colon | Anemia |
CRC_20 | f | 20.3 | 20.8 | Necropsy | pos | US & CT | 2 | 0 | 0 | 2 | pos | AdenoCa | Ileocecal junction | Anemia |
CRC_21 | f | 21.0 | 21.2 | Biopsy | n.A | n.A | 3 | 1 | 0 | 3 | pos | AdenoCa | Proximal colon, metastasis: mesenteric LN | Cachexia, anemia, esophageal hyperplasia due to chronic gastric reflux |
CRC_22 | m | 17.8 | 18.4 | Necropsy | pos | US & CT & FDG-PET | 3 | 0 | 0 | 2 | pos | AdenoCa | Proximal colon, small vessel invasion | Anemia |
CRC_23 | f | 18.1 | 18.7 | Necropsy | pos | US & CT | 2 | 0 | 0 | 1 | pos | AdenoCa | Ileocecal junction | Anemia |
CRC_24 | f | 18.7 | n.A | Biopsy | neg | US & CT | 3 | 0 | 0 | 3 | pos | Mucinous AdenoCa | Ileocecal junction | st. p. tumor resection |
Average | 20.3 | 21.3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |