Fig. 3

The mutational signature of rhesus CRCs is congruent to the human SBS6 signature with dMMR as proposed etiology. Most base substitutions observed in rhesus CRC are C > T transitions with a clear enrichment for ACG, CCG, GCG, and TCG. This pattern is highly similar to the human SBS6 signature [43], which is strongly associated with mismatch repair deficiency