Fig. 6

Slice 1: heterogeneity in spatial metabolic activity. A Pathological section of spatial transcriptomics. B Approximate distribution of various cell types. C Partitioning of spatial transcriptomics data, colored by distance from the tumor center. D Correlation of metabolic pathways (glycolysis, TCA cycle, fatty acid metabolism, tyrosine, and purine metabolism) with distance from the tumor center. E Correlation of biological pathway activities (EMT, angiogenesis, inflammation, TGF-beta, and NOTCH) with distance from the tumor center. F Heatmap of balance flux for AMP, CDP, and fatty acids in the spatial context. G Heatmap of balance flux for acetyl CoA, ornithine, and tyrosine in the spatial context. H Heatmap of balance flux for succinate, glutamate, and fumarate in the spatial context. EMT—Epithelial–Mesenchymal Transition