Fig. 5

Endothelial cell expression heterogeneity. A UMAP plot of endothelial cells, color-coded by cell subtypes. B Enrichment heatmap of different endothelial cell subtypes across various ISUP grades of tumor tissue. C Impact of CRHBP⁺ CAP endothelial cell enrichment on patient prognosis. D Differential genes among cell subtypes derived from tumor and normal sources: Left-Arterial endothelial cells; Middle-Capillary endothelial cells; Right-Venous endothelial cells. E UMAP plot of endothelial cells, color-coded by expression of ENPP2 gene. F Patient prognosis stratified by ENPP2 expression levels. ISUP: International Society of Urological Pathology.UMAP: Uniform Manifold Approximation and Projection