Fig. 4
Macrophage metabolism and its highly correlated biological significance. A UMAP plot of macrophages, color-coded by cell subtype. B UMAP plot of macrophages, color-coded by metabolic subtype. C Metabolic activity heatmap of macrophages across different metabolic subtypes. D Infiltration enrichment heatmap of macrophage subtypes in different polarizations, ISUP histological grades, and tumor grades. E Dynamic changes in enrichment levels of different macrophage subtypes along the inferred pseudotime trajectory. F Dynamic changes in annotated metabolic pathway activity of macrophage metabolic subtypes along the inferred pseudotime trajectory. G Dynamic changes in macrophage feature activity along the inferred pseudotime trajectory. H Dynamic changes in energy metabolism activity of macrophages along the inferred pseudotime trajectory. I Dynamic changes in amino acid metabolism activity of macrophages along the inferred pseudotime trajectory. J Correlation heatmap between macrophage feature activity and various metabolic pathway activities. K Transcription factor activity heatmap of macrophages, where red indicates high activity and blue indicates low activity. IMP: Inositol phosphate metabolism; AA: Arachidonic acid metabolism; OXP: Oxidative phosphorylation; GLY: Glycolysis; FATTY: Fatty acid metabolism; ISUP: International Society of Urological Pathology.UMAP: Uniform Manifold Approximation and Projection