Fig. 2

Evident enhanced glycolytic activity in tumor cells of clear cell renal cell carcinoma. A Forest plot depicting the differential activity of multiple metabolic pathways between tumor cells and normal epithelial cells, with different background colors representing distinct metabolic categories. B Differential expression of genes related to Glycolysis and Tricarboxylic Acid (TCA) Cycle between tumor cells and normal epithelial cells, highlighted in red for high expression in tumor cells and blue for high expression in normal epithelial cells. C Correlation heatmap showing the association between glycolytic activity in tumor cells and various biological functions. D Correlation heatmap of different states of tumor cells, where red indicates high correlation and blue indicates low correlation. EMT: Epithelial–Mesenchymal Transition; Oxp: Oxidative Phosphorylation