Fig. 1

High-resolution single-cell atlas of clear cell renal cell carcinoma. A UMAP visualization of ccRCC, with the inner ring representing cell type proportions and the outer ring indicating tissue origin proportions. B Dot plot illustrating marker gene expression for major cell types. C Heatmap displaying sample information, tumor microenvironment classification groups, and cell infiltration enrichment levels for tumor samples. D Heatmap showcasing cell infiltration enrichment levels in the tumor microenvironment across different ISUP histological grades and sampling sites. ISUP: International Society of Urological Pathology; UMAP: Uniform Manifold Approximation and Projection