Fig. 4

The display and evaluation of the nomogram model for predicting TSC response. A A nomogram predicting the probability of TSC response. B Receiver-operating characteristic curves for the TSC nomogram. C The calibration curves for the TSC nomogram. The 45◦ dashed line is a reference line that shows perfect prediction. The red dotted line is the performance of the nomogram, while the green solid line corrects for any bias in the nomogram. D Decision-curve analysis for the TSC nomogram. The y-axis represents the net benefit and the x-axis shows the threshold probability of response. The ‘Treat All’ line refers to the hypothesis that all patients were treated with ixekizumab and the ‘Teart None’ line to the assumption that no patient was treated with ixekizumab. TSC total skin clearance