Fig. 4
Tumor angiogenesis may impede the infiltration of TRM cells. A Gene set map showing the top 20 biological pathways enriched in the low ITGAE (coding CD103) expression group in gene set enrichment analysis (GSEA), mostly related to angiogenesis or immunity. B Detailed enrichment profiles for the three main angiogenesis-correlated pathways in GSEA. C Gene overlapping rate among the main three angiogenesis-correlated pathways in GSEA. D Correlation among the expression of CD103, overlapped genes (NRP1, VEGFC, ITGB3), and hypoxia indicator (HIF1A). E The merged and single-stained images for the panel of multiplex immunofluorescence. F Correlation among TRM cells, cancer microvessels (CMVs) (indicated by CD31), and hypoxia (indicated by Hif-1α). The correlation was calculated using the Spearman rank correlation coefficient. *P < 0.05; **P < 0.01; ***P < 0.001