Fig. 6

EXO1 inhibited P53 signaling in PCa. A GSEA analysis using the TCGA-PRAD project showed that EXO1 was associated with the activation and regulation of the P53 signal pathway B Scatter plots using the TCGA-PRAD program with EXO1 expression as the horizontal coordinate and PCNA and CDC25 expression as the vertical coordinate. C P53 Immunohistochemistry in 4 PCa of carcinoma and paraneoplastic. D, E Knockdown of EXO1 in prostate cancer cells and detection of P53 expression using Western blot and qPCR. F–I Expression of PCNA and CDC25 was detected by qPCR after the knockdown of EXO1. J, K After overexpression of EXO1 in prostate cancer cells, the expression level of P53 was detected using Western blot and qPCR. L–O After overexpression of EXO1, qPCR was used to detect the expression of PCNA and CDC25