Fig. 2

Expression of insulin receptors was significantly reduced in colitis both in IBD patients or animal model. a–f Expression of INSR in human ulcerative colitis mucosa. Sequencing data GSE38713, GSE75214, GSE59071, GSE65114, GSE47908 and GSE87466 were selected from GEO database. g mRNA INSR expression of IELs and LPLs in Control and DSS group were analyzed by qPCR. n = 3. h, i INSR expression of in IELs, LPLs, intestinal epithelial cells (IECs) and LPs (without LPLs). INSR expression were detected by Flow staining and calculate by Mean fluorescence intensity. (IELs and LPLs: n = 5; IECs and LP cells without LPLs: n = 3)