Fig. 7

Prognosis of patients with non-small cell lung cancer with and without interstitial pneumonia (IP) A Definition of patients with lung cancer with IP [IP ( +)] and without IP [IP (−)] among the enrolled patients with NSCLC treated with surgery (cohort 1). NSCLC, non-small cell lung cancer. UIP, usual interstitial pneumonia. ECOG PS, Eastern Cooperative Oncology Group Performance Status. COPD, chronic obstructive pulmonary disease. B–C Kaplan–Meier survival curves for B recurrence-free survival (RFS) and C cause-specific survival (CSS) periods between the IP ( +) and IP (−) groups in cohort 1. D Definition of patients with lung cancer with IP [IP ( +)] and without IP [IP (−)] among the enrolled patients with NSCLC treated with chemotherapy (cohort 2). E Kaplan–Meier survival curves for CSS between the IP ( +) and IP (−) groups in cohort 2. F HIF-1α, TIMP-1, VEGFA, and Ki-67 expression in tumor specimens of the IP ( +) and IP (−) groups in cohort 2. Representative images of tumor specimens stained with an antibody against human HIF-1α, TIMP-1, VEGFA, and Ki-67 via immunohistochemistry