Fig. 1
From: Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression
Novel murine model of lung cancer with interstitial pneumonia (IP) A Experimental scheme of the development of the mouse model of lung cancer with (IP + LC) or without (LC) interstitial pneumonia. LLC and KLN205 cells were the injected cancer cells. O.A., oropharyngeal administration. BLM bleomycin. B Hematoxylin and eosin staining of lung sections and macroscopic evaluation of the LC and IP + LC models on day 28. Scale bar: 300 μm. C–E Comparison of C tumor volume, D weight of mediastinal lymph nodes, and E number of metastatic foci between the LC and IP + LC models on day 28 (n = 5–7/group). *P < 0.05, **P < 0.01, ****P < 0.001