Fig. 4
From: Macrophage metabolism, phenotype, function, and therapy in hepatocellular carcinoma (HCC)
The mechanisms of therapeutics for HCC through regulating macrophage metabolism. A ACCS modulates glycolysis metabolism, leading to the induction of M1-like polarization in macrophages. This metabolic shift not only suppresses HCC cell survival but also exerts potent anti-tumor effects. B The combination of decitabine and etomoxir acts on macrophages by regulating FAO and amino acid metabolism, thereby promoting M1-like polarization. This synergistic effect contributes to the therapeutic potential against HCC. C Celecoxib, through the inhibition of COX-2-related PGE2 production, facilitates the promotion of M1-like polarization in macrophages