Table 2 Toxicokinetic parameters of Gensci059 in cynomolgus monkeys following multiple-dose administration
| Â | 1st dose | 2nd dose | 4th dose | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|  | Cmax (mg/mL) | AUClast (h·mg/mL) | AUCinf (h·mg/mL) | Cmax (mg/mL) | AUClast (h·mg/mL) | AUCinf (h·mg/mL) | Cmax (mg/mL) | AUClast (h·mg/mL) | AUCinf (h·mg/mL) | AF (AUC4th/2nd) |
Low dose | 0.19 ± 0.01 | 3.1 ± 0.48 | 3.1 ± 0.48 | 0.73 ± 0.08 | 27.33 ± 2.88 | 28.53 ± 2.94 | 0.77 ± 0.31 | 34.12 ± 21.36 | 36.34 ± 22.96 | 1.25 |
Middle dose | 0.19 ± 0.04 | 3.11 ± 0.54 | 3.11 ± 0.54 | 2.46 ± 0.23 | 149.24 ± 22.96 | 173.14 ± 28.15 | 2.92 ± 0.32 | 155 ± 61.03 | 234.92 ± 132.32 | 1.04 |
High dose | 0.21 ± 0.02 | 3.51 ± 0.58 | 3.51 ± 0.58 | 8.89 ± 0.71 | 521.26 ± 60.07 | 737.03 ± 174.88 | 7.98 ± 1.31 | 556.2 ± 178.94 | 1001.69 ± 503.81 | 1.07 |