Fig. 9
PTPRH increased invasion, FDG uptake and lactate levels via PI3K/AKT/mTOR signaling pathway-mediated glycolysis. A, B Transwell assays to detect the individual and combined effects of sh-PTPRH and the PI3K activator 740Y-P and OE-PTPRH and the PI3K inhibitor LY294002 on the invasion ability of H460 and A549 cells. C, D 18F-FDG uptake assays to detect the individual and combined effects of sh-PTPRH and the PI3K activator 740Y-P and OE-PTPRH and the PI3K inhibitor LY294002 on the FDG uptake ability of H460 and A549 cells. E, F Cell metabolism assays to detect the individual and combined effects of sh-PTPRH and the PI3K activator 740Y-P and OE-PTPRH and the PI3K inhibitor LY294002 on the lactate levels of H460 and A549 cells. G A diagram showing the possible mechanism underlying the modulation of glycolysis by PTPRH