Fig. 8

MEX3C accelerates lung cancer metastasis in vivo. A Nude mice were injected subcutaneously with A549 and H1299 cells expressing either si-NC or si-MEX3C. The tumor metastasis was detected by using IVIS^® bioluminescence imaging system 8 weeks after injection. Quantitative data of tumor metastases detected by IVIS system. B, C The lungs were removed and imaged 8 weeks after injection via the tail vein. The number of metastatic nodules in the lungs was counted. D The H&E staining of lung tissues from different group of mice, scale bar, 50 μm. E Western blot analysis was performed to detect the protein expression of MEX3C, RUNX3, and Suv39H1, E-cadherin and N-cadherin. Data were expressed as mean ± SD, n = 5, **P < 0.01