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Table 4 PIK3CA status of organoid lines detected by Next Generation Sequencing

From: Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer

Organoid

PIK3CA status

DNA

cDNA change

AA change

Allele frequency

CRC-1

Mutated

chr3 179,218,294

G to A

c.G1624A

p.E542K

57.5%

CRC-2

Wildtype

–

–

–

–

CRC-2T2

Wildtype

–

–

–

–

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Journal of Translational Medicine

ISSN: 1479-5876

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