Fig. 7

Schematic diagram of the molecular mechanism by which transcription factors LHX9 regulates pyruvate kinase PKM2 activity to mediate the reprogramming of glycolytic metabolism in cancer stem cells to affect gastric cancer progression. High expression of CLDN9 can be used as an independent influence factor for prognosis prediction in GC patients, and its predictive efficacy is better with longer survival time; high expression of MET and MIOX can be used as reference markers for prognosis prediction in GC patients, and their predictive efficacy is better with longer survival time, but they are not independent prognostic factors for GC patients; high expression of TKTL1 and CHST4 cannot be used as prognostic TKTL1 and CHST4 high expression cannot be used as reference markers and independent impact factors for prognosis of GC patients