Fig. 6

ATR and FA/HR co-mutations were specifically associated with more nucleotide-level changes and poor prognosis. A–C The comparison of TMB (A), CIS (B), and MSI frequency (C) in patients from the study cohort who were stratified by different ATM/ATR and FA/HR mutational statuses. D Kaplan–Meier curve of overall survival in NSCLC patients from the external cohort in strata of different ATM/ATR and HR mutational statuses. E Kaplan–Meier curve of overall survival in NSCLC patients from the external cohort in strata of different ATM/ATR and FA/HR mutational statuses. F The immune infiltration level stratified by different ATM/ATR mutational statuses and histological subtypes. The results were analyzed using Timer 2.0, which is based on the gene mutation and expression data from the TCGA database