Fig. 1

PIKK pathogenic mutations were accompanied by high mutational loads and microsatellite instabilities. A, B The lollipop plots of the pathogenic mutations of ATM (A) and ATR (B) detected in the study cohort. (C) The tumor mutational burden (TMB) in PIKK-mutated (Mut) and PIKK-wild type (WT) NSCLC patients from the study cohort. D The comparison of TMB between different PIKK mutational statuses and histological subtypes in the study cohort. E, F The comparison of microsatellite instability (MSI) between PIKK-mutated and PIKK-WT NSCLC patients for all patients (E) or ADC patients (F) from the study cohort. G The chromosomal instability score (CIS) between PIKK-mutated and PIKK-WT NSCLC patients from the study cohort