Fig. 7

The role of relevant cell clusters in sepsis PBMCs. A The strength of outgoing and incoming signals of cell clusters in controls (left) and septic patients (right). B Heatmap of differential interactions of clusters in the cell–cell communication network. The top bar indicates the sum of incoming signaling, and the right bar indicates the sum of outgoing signaling. C Differential interaction strength between C10_ULK1 (outgoing) and other cell clusters (incoming). D Heatmap showing the relative importance of outgoing signaling in each cell group in controls (left) and septic patients (right). E Comparison of significant ligand-receptor pairs between controls and septic patients. F The expressions of RETN (up) and CAP1 (down) in different cell clusters. G All the signaling pathways of controls and sepsis samples are presented in relative information flow (left) and overall information flow (right). H Two-dimensional manifold projection of signaling pathways based on their functional similarity