Fig. 5

Decipherment of the tumor immune microenvironment based on circulating MAPS. A, B Volcano plot A and ranking chart B of the immune-related DEGs in tumors between circulating MAPS-high and MAPS-low groups. C GO and KEGG enrichment analysis based on the immune-related DEGs. D Kaplan–Meier OS curves of 12 immune-related DEGs. The P value was calculated by log-rank test between DEG-high and DEG-low groups. E Bubble plot of the relationship between 14 model microbes, circulating MAPS score and 12 OS-related immune DEGs. F Differences in xCell scores of plasma B cells and CD4⁺ Th2 cells between circulating MAPS-high and MAPS-low groups. G–I Differences in PD-L1 expression levels G, CTLA4 expression levels H and the TIDE scores I between circulating MAPS-high and MAPS-low groups