Fig. 6

Radiogenomics linking four MRI sequences consist of 20 prognostic radiomic features and their significantly associated pathways. A The mantel test results of the number and category of biological pathways behind each sequence. B Heatmap of four sequences along with their top 10 significantly associated pathways represented by their pathway gene set variation analysis (GSVA) score across the radiogenomics analysis set with risk groups, Radscore, overall survival, and survival status. The 10 rows immediately after each sequences represented by these prognostic features indicate the activation level (in gene set variation analysis score) of the top 10 significant pathways. C Mantel test results between four MRI sequences and typical pathways derived from three biological pathway categories