Fig. 5

Radiogenomics linking between 20 radiomic features constituting the Radscore and their significantly associated pathways. A Venn diagram and Pie chart of the intersective pathways. B A heatmap showing the activation of 318 intersective pathways clustered according to their corresponding biological pathway categories (proliferation, immunity, DNA damage response) in a high- and low-risk group of 132 patients. C Bar charts revealed the number of biological pathways behind individual features. Fourteen features derived from different MRI sequences have 219 different pathways (proliferation of 131, immune of 46, DDR of 42) associated behind them. D A bubble plots of correlation between prognostic radiomic features and classic biological pathways. Correlation results for the top 5 correlated pathways (FDR < 0.01) and prognostic features in each pathway category