Table 2 Diagnostic efficacy of radiomics signature in prediction of KIT-11 mutation genotype in the training and validation cohort
| Â | Training cohort | Validation cohort | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No mutation | Point mutations or duplications | deletions not involving codons 557/558 | KIT exon 11 557/558 deletions | Micro averaging | Macro averaging | No mutation | Point mutations or duplications | deletions not involving codons 557/558 | KIT exon 11 557/558 deletions | Micro averaging | Macro averaging | |
Accuracy | 0.862 (0.835–0.889) | 0.741 (0.706–0.775) | 0.929 (0.908–0.949) | 0.856 (0.828–0.883) | 0.781 (0.755–0.808) | 0.694 (0.66–0.729) | 0.819 (0.787–0.852) | 0.753 (0.716–0.79) | 0.875 (0.846–0.903) | 0.827 (0.795–0.859) | 0.743 (0.714–0.772) | 0.637 (0.595–0.679) |
Sensitivity | 0.545 (0.46–0.629) | 0.798 (0.748–0.849) | 0.759 (0.679–0.84) | 0.598 (0.515–0.682) | 0.694 (0.656–0.734) | 0.694 (0.66–0.729) | 0.522 (0.438–0.607) | 0.781 (0.723–0.84) | 0.607 (0.505–0.708) | 0.55 (0.457–0.642) | 0.637 (0.593–0.681) | 0.637 (0.595–0.679) |
Specificity | 0.95 (0.931–0.97) | 0.703 (0.657–0.75) | 0.965 (0.949–0.981) | 0.926 (0.902–0.949) | 0.898 (0.885–0.911) | 0.85 (0.828–0.869) | 0.921 (0.894–0.948) | 0.737 (0.689–0.784) | 0.929 (0.905–0.953) | 0.901 (0.872–0.93) | 0.879 (0.864–0.894) | 0.851 (0.831–0.871) |
PPV | 0.753 (0.667–0.838) | 0.636 (0.582–0.69) | 0.82 (0.745–0.895) | 0.687 (0.602–0.772) | 0.694 (0.656–0.734) | 0.704 (0.671–0.74) | 0.693 (0.603–0.783) | 0.63 (0.569–0.692) | 0.635 (0.533–0.738) | 0.598 (0.503–0.693) | 0.637 (0.593–0.681) | 0.639 (0.6–0.683) |
NPV | 0.883 (0.855–0.91) | 0.843 (0.803–0.883) | 0.95 (0.931–0.969) | 0.894 (0.868–0.921) | 0.898 (0.885–0.911) | 0.881 (0.861–0.897) | 0.849 (0.815–0.883) | 0.854 (0.813–0.895) | 0.921 (0.895–0.946) | 0.882 (0.851–0.913) | 0.879 (0.864–0.894) | 0.87 (0.851–0.887) |