Fig. 3

Construction of a risk prognostic model based on PRGs in the TCGA cohort. A Forest plots for hazard ratios (HRs) of differentially expressed PRGs in SKCM. B Partial likelihood deviance versus log (λ) was plotted using LASSO Cox regression model. C Coefficients of selected features are shown by lambda parameter. D Risk score analysis of 8 PRGs prognostic signature. In the top panel, patients were evenly divided into two groups based on the median risk score, with blue indicating the low-risk group, and red indicating the high-risk group. The middle panel shows the survival status of patients with SKCM, with blue dots representing survival, and red dots representing death. The bottom panel depicts the expression of the eight PRGs, with blue indicating the low-risk group, and red indicating the high-risk group. E Kaplan–Meier survival curves showing the overall survival of patients in the high-risk and low-risk groups. F Time dependent ROC curves verifying the predictive efficiency of the risk score