Fig. 2

Cantharidin suppresses breast cancer cells growth and induces apoptosis dependent on EGFR levels. A Protein levels of EGFR in lentivirus transfected MDA-MB-231, MDA-MB-468 and MCF-7 cells. B Effects of cantharidin on cell proliferation in wild-type (shCtrl), EGFR-knockdown (shEGFR) and EGFR-restored (shRNA + EGFR) MDA-MB-231 cells. C Effects of cantharidin on cell proliferation in wild-type, EGFR-knockdown and EGFR-restored MDA-MB-468 cells. D Effects of cantharidin on cell apoptosis in wild-type, EGFR-knockdown and EGFR-restored MDA-MB-231 cells. E Effects of cantharidin on cell apoptosis in wild-type, EGFR-knockdown and EGFR-restored MDA-MB-468 cells. F Effects of cantharidin on cell proliferation in wild-type, EGFR-overexpressed MCF-7 cells. G Effects of cantharidin on cell apoptosis in wild-type (Control), EGFR-overexpressed (EGFR) MCF-7 cells. Data were expressed as mean ± SEM (n = 3), *p < 0.05, **p < 0.01, ***p < 0.001