Fig. 3

Transcriptome profiling of PDTX-model-originating patients. A, B Differentially expressed genes (DEGs) between GC tissue and normal tissue in the tumorigenesis group (A) and non-tumorigenesis group (B). Red dots represent highly expressed genes in GC tissue with P < 0.05 and a fold change > 1.6, and blue dots represent down-regulated genes in GC tissue with P < 0.05 and a fold change < 0.625. C, D Heatmap of DEG expression levels in the tumorigenesis group (C) and non-tumorigenesis group (D). E Venn diagram of DEGs in the tumorigenesis and non-tumorigenesis group. F–H Gene Ontology (GO) enrichment bar plots of 383 unique DEGs in the tumorigenesis group for cellular component (red), biological process (green), and molecular function (blue) terms. Colored titles are extracellular matrix (ECM)-related pathways