Fig. 2

UVR-induced changes in skin appearance. Digital photographs of mice exposed to UV. A Diagram of experiment design of UVR cSCC mice. B Establishment of UV-induced cSCC mice model. By the eighth week of UVR, the skin showed typical photoaging manifestation. From the 12th to 14th week of UVR, needle-tip-size papules appeared. After 16 weeks of UVR, the number and size of papules increased. Exposure to UV for 20 weeks, cSCC lesions appeared. C, D and E Diagram of experiment design of Evans Blue assay. W, weeks; min, minute; h, hour; d, day