Fig. 3

The genomic characteristics of primary tumors and matched P1-P4 generations PDX models. a Genome-wide amplifications and deletions in cervical cancer PDX tumors (10 pairs) b Copy number (CN) differences among primary tumor (PT), matched P1 and P2 PDX tumors of patient CAT082. Red, CN gain; Green, CN loss. c CN differences among PT, matched P1 and P4 PDX tumors of patient CAT061. Red, CN gain; green, CN loss. d The percentage of discordant CN alternation of genome between PT and P1 tumor, or between P1 and P2 tumor. e The oncogenic mutation status of selected genes in primary tumors and paired PDX models that are successfully engrafted in mice (n = 10). f The tumor mutation burden and the alteration status of selected cancer-associated genes in primary tumors and paired PDX tumors. g AID/APOBEC mutational signatures (signatures 2 and 13) in CAT082 and CAT145