Fig. 2

The histological characteristics of primary tumors and matched P1–P4 generations PDX models. a. Cervical cancer primary tumor and corresponding PDX models (P1–P4) showed similar histological features as assessed by hematoxylin and eosin and immunohistochemical staining: PDX tumor showed similar levels of α-smooth muscle actin (α-SMA), p16, and Ki67 staining of their parental tumors. b, c Quantitation of the epithelial and stromal components of the primary tumor and corresponding PDXs (n = 32). d, e. Quantitation of Ki67 staining in the epithelial fraction (n = 20). f, g. Quantitation of α-SMA staining in the stromal fraction (n = 20). Scale bar = 50 μm