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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Rutaecarpine induces the differentiation of triple-negative breast cancer cells through inhibiting fumarate hydratase

Fig. 3

Rutaecarpine induces differentiation of TNBC cells through elevated ROS. A. GSEA analysis showing significant enrichment of ROS genes. B. Spheroid formation from MDA-MB-231 and BT549 cells with the treatment of DMSO or rutaecarpine and NAC. C. Quantification of circularity and Feret’s diameter for spheroids formed by MDA-MB-231 and BT549 cells. One-way ANOVA; **** p < 0.0001. D. FCM analysis of the MFI of ROS in cells from spheroids. E. Quantification of ROS level in cells from spheroids. One-way ANOVA; **** p < 0.0001. F. qPCR of luminal differentiation genes in cells from MDA-MB-231 and BT549 spheroids with different treatment. One-way ANOVA; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001

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Journal of Translational Medicine

ISSN: 1479-5876

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