Table 2 Associations between categorized BPH/PV-related PRS and risk of prostate cancer-specific mortality in prostate cancer prognosis cohort
75–100th PRS | 50–75th PRS | 25–50th PRS | 0–25th PRS | P-trend | |
|---|---|---|---|---|---|
Mean age at PCa death (SD), yr | 72.2 (5.0) | 71.9 (5.1) | 71.6 (5.7) | 71.1 (5.5) | 0.17 |
Proportion of deceased | 5.5% (199/3,638) | 6.6% (241/3637) | 7.1% (260/3,637) | 7.1% (259/3,637) | 0.01 |
ORa (95%CI) | 1 (Ref.) | 1.36 (1.10–1.69) | 1.44 (1.16–1.79) | 1.37 (1.10–1.70) | 4.95 × 10–3 |
HRa (95%CI) | 1 (Ref.) | 1.33 (1.11–1.61) | 1.34 (1.11–1.62) | 1.41 (1.17–1.71) | 7.52 × 10–4 |
5-year survival probability (95% CI, %) | 96.3 (95.7–97.0) | 95.9 (95.2–96.6) | 94.9 (94.1–95.6) | 94.8 (94.0–95.6) | 3.10 × 10–3 |
10-year survival probability (95% CI, %) | 93.5 (92.6–94.5) | 92.2 (91.2–93.3) | 91.7 (90.6–92.8) | 91.6 (90.3–92.6) | 8.44 × 10–5 |
20-year survival probability (95% CI, %) | 87.4 (84.0–90.8) | 84.5 (81.4–87.8) | 84.2 (81.0–87.5) | 83.7 (80.4–87.1) | < 2.20 × 10–16 |
Restricted mean survival time (95% CI, %) | 0 (Ref.) | − 0.01 (− 0.26 to 0.24) | − 0.09 (− 0.34 to 0.15) | − 0.37 (− 0.61 to − 0.14) | 1.88 × 10–3 |