Table 1 Demographic and clinical characteristics of prostate cancer patients in UK Biobank
Characteristics | Lethal PCa | Non-lethal PCa | All | P valueb |
|---|---|---|---|---|
Male participants, No. (%) | 959 (6.6) | 13,590 (93.4) | 14,549 | |
Age at diagnostic, mean (SD), yr | 65.8 (6.2) | 66.9 (6.5) | 66.9 (6.5) | 0.013 |
Age at death, mean (SD), yr | 71.6 (5.3) | 73.5 (5.1)a | 72.7 (5.3) | < 0.001 |
BPH diagnosis, No. (%) | 0.004 | |||
Yes | 151 (15.7) | 2657 (19.6) | 2808 (19.3) | |
No | 808 (84.3) | 10,933 (80.4) | 11,741 (80.7) | |
Family history of PCa, No. (%) | 0.949 | |||
Yes | 114 (11.9) | 1617 (11.9) | 1731 (11.9) | |
No | 799 (83.3) | 11,402 (83.9) | 12,201 (83.9) | |
Missing | 46 (4.8) | 571 (4.2) | 617 (4.2) | |
Charlson comorbidity index scores | < 0.001 | |||
0 | 108 (11.3) | 4441 (32.7) | 4549 (31.3) | |
1–2 | 112 (11.7) | 5906 (43.4) | 6018 (41.4) | |
> 2 | 739 (77.0) | 3243 (23.9) | 3982 (27.3) | |
Genetic kinship | 0.098 | |||
No kinship found | 644 (67.2) | 9447 (69.5) | 10,091 (69.3) | |
At least one relative identified | 314 (32.7) | 4136 (30.4) | 4450 (30.6) | |
Ten or more third-degree relatives | 1 (0.1) | 7 (0.1) | 8 (0.1) | |
WES data, No. (%) | 392 (40.9) | 5504 (40.5) | 5896 (40.5) | 0.808 |