Fig. 7

T-96 ameliorated the depigmentation of vitiligo by JAK-STAT signaling. A The high levels of IFN-γ in the skin generate abundant chemokine production of keratinocytes via IFN-γ-JAK2-STAT1-CXCL9/10 pathway. B CXCL9/10 recognize CXCR3 and result in the recruitment of CXCR3⁺CD8⁺ T cells. C Autoreactive CD8⁺ T cells destroy melanocytes using cytotoxic granules granzyme B (GzmB) and perforin (PRF) and establish a high IFN-γ profile. D T-96 decreased the production of chemokines in keratinocytes targeting IFN-γ-JAK2-STAT1 signaling, blocked the migration of CXCR3⁺CD8⁺ T cells, suppressed the effector function of CD8⁺ T cells, and finally rescued the loss of melanocytes