Fig. 1

T-96 ameliorated ongoing depigmentation by inhibiting the CD8⁺ T cells skin infiltration in a mouse model of vitiligo. A Schematic diagram of vitiligo induction and treatment. B Schematics of the whole-mount view of tail skin. C Initial accumulation of CD8⁺ T cells around follicles. Scale bar = 100 μm. D Strong accumulation of CD8⁺ T cells in close vicinity to melanocytes. Scale bar = 100 μm. E The representative mouse tail images. F Statistical analysis of the extent of pigment loss. G Representative whole-mount tail epidermis immunofluorescence staining at indicated treatments for five weeks. Scale bar = 200 μm. Three replicate experiments were performed for a total of 6 mice per group. *P < .05, ****P < .0001. ns not significant