Fig. 4

Establishment of TAO model in mice by immunization with TSHR adenovirus. A The body weight of mice in the control and model groups every week from week 1 to 24. B Representative images of mice (lateral appearances) in different groups. C, D H&E and Masson staining of orbital adipose and fibrous tissues. E Mice serum T4, TSH, and TRAb levels determined using ELISA