Fig. 3

Effects of CD40Apt on the activation of intracellular CD40 and downstream signaling pathways Orbital fibroblasts were challenged with 10 ng/ml TGF-β for 48 h, treated with PBS, non-specific control aptamer, or 500 nM CD40Apt for 48 h, and examined for the protein levels of p-Erk, Erk, p-p38, p38, p-JNK, and JNK using Immunoblotting (A); the protein levels of p-NF-κB and NF-κB using Immunoblotting (B)