Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort

Table 3 Differentially abundant bacterial genera between the participants with low F_eNO vs. high F_eNO levels detected by ANCOM-BC (n = 477)

Genus	Phylum	Low F_eNO	Intermediate F_eNO	High F_eNO	Lipid A annotation
Genus	Phylum	(< 25 ppb^a)	(25–49 ppb)	(≥ 50 ppb)	Lipid A annotation
Achromobacter	Proteobacteria	0.81	0.19	0.00	Penta
Aerococcus	Firmicutes	0.92	0.08	0.00	Gram-positive
Agrobacterium	Proteobacteria	0.74	0.25	0.01	Penta
Bacteroides	Bacteroidetes	0.73	0.26	0.02	Penta
Bosea	Proteobacteria	0.87	0.12	0.00	Penta
Brevundimonas	Proteobacteria	0.68	0.32	0.00	Penta
Clostridiales_[F-1][G-2]	Firmicutes	0.97	0.03	0.00	Gram-positive
Clostridiales_[F-3][G-1]	Firmicutes	0.86	0.14	0.00	Gram-positive
Cutibacterium	Actinobacteria	0.80	0.20	0.01	Gram-positive
Dermabacter	Actinobacteria	0.65	0.33	0.02	Gram-positive
Erysipelothrix	Firmicutes	0.82	0.17	0.01	Gram-positive
Helicobacter	Proteobacteria	0.81	0.17	0.02	Penta
Janibacter	Actinobacteria	0.79	0.20	0.01	Gram-positive
Kocuria	Actinobacteria	0.77	0.22	0.00	Gram-positive
Lachnospiraceae_[G-7]	Firmicutes	0.81	0.19	0.00	Gram-positive
Lactobacillus	Firmicutes	0.80	0.20	0.00	Gram-positive
Lysinibacillus	Firmicutes	0.72	0.26	0.02	Gram-positive
Mitsuokella	Firmicutes	0.94	0.06	0.01	Penta
Mogibacterium	Firmicutes	0.78	0.22	0.00	Gram-positive
Moraxella	Proteobacteria	0.95	0.05	0.00	Penta
Novosphingobium	Proteobacteria	0.68	0.31	0.00	Penta
Paenibacillus	Firmicutes	0.62	0.36	0.02	Gram-positive
Pedobacter	Bacteroidetes	0.64	0.35	0.01	Penta
Peptostreptococcaceae_[XI][G-2]	Firmicutes	0.85	0.14	0.01	Gram-positive
Saccharibacteria_(TM7)_[G-4]	Saccharibacteria	0.58	0.40	0.02	Gram-negative
Schlegelella	Proteobacteria	0.84	0.15	0.01	Penta
Staphylococcus	Firmicutes	0.82	0.17	0.01	Gram-positive

Data are presented as relative abundances for each genus per F_eNO category. The lipid A annotation of penta-acylated LPS producers is indicated as “Penta”
^appb parts per billion

ISSN: 1479-5876