Fig. 2
From: ST6GALNAC4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation
Knockdown of ST6GALNAC4 attenuated HCC cell proliferation, migration, and invasion in vitro. We used small interfering RNAs (siRNAs) to knock down ST6GALNAC4 expression in HCC cells. ST6GALNAC4 knockdown resulted in the reduced proliferative capacity of HCCLM3 (A) and MHCC97H (B) detected by CCK-8 and colony formation assay. ST6GALNAC4 knockdown resulted in impaired migratory and invasive capabilities of HCCLM3 (C, E) and MHCC97H (D, F). scale bar, 200 \(\mu\)m; magnification, ×100. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. ns, not significant