Fig. 1

Expression of ISG15 and lymphcytes in lung adenocarcinoma. A Activation of memory CD4⁺ T cells, infiltration of CD8a⁺ T cells and expression of CD8⁺ T lymphocytotoxic factors in high/low ISG15 expressing tumour tissues obtained from the TCGA collection. B Representative IHC images showing the expression of ISG15, CD3, CD4, CD8. Scale bars 100 μm. Magnification, ×100, ×400. C The relationship between CD3⁺, CD4⁺, CD8⁺ T cells and ISG15 was analysed by IHC staining of LUAD