Fig. 2
![Fig. 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12967-023-04001-0/MediaObjects/12967_2023_4001_Fig2_HTML.png)
Differentially expressed genes and gene set enrichment analysis (GSEA) with high and low CAPRIN1 expression groups. A The heat map of the top 25 genes positively (red) and negatively (blue) correlated with CAPRIN1 in the TCGA-ESCA database. B The top 20 hub genes screened in the PPI network using the cytoHubba module of Cytoscape (higher color represents stronger connectivity). C The most significantly enriched GO annotations and KEGG pathways D of CAPRIN1 in the GEO database (GSE69925) by GSEA