Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12967-023-03935-9/MediaObjects/12967_2023_3935_Fig1_HTML.png)
Differential sensitivity of cancer cells to STS and DXR is associated with enhanced ROS production in triple negative breast cancer cells. a Starvation in combination with 100 nM DXR treatment selectively inhibits cellular proliferation (Hoechst) in MDA-MB-231, MDA-MB-468 and HS578 cancer cells but not in the near normal MCF-10 cell line. Scale bar: 1 mm. b Starvation in combination with 100 nM DXR treatment selectively increases cell death (PI) in MDA-MB-231, MDA-MB-468 and HS578 cancer cells but not in the near normal MCF-10 cell line. c Assessment of intracellular ROS production. Data are presented as mean of the fold change ± SD of intracellular ROS production in MDA-MB-231, MDA-MB-468 and HS578 and MCF-10A cells upon STS, DXR or combined STS + DXR treatment. *P ≤ 0.05. d Assessment of intracellular ROS production. Data are presented as mean of the fold change ± SD in MDA-MB-231 cells treated with STS with or without the MTH1 inhibitor TH1579. *P ≤ 0.05