Fig. 6
From: Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma
PFKFB3 inhibition inhibits the activation of the PI3K/Akt signaling pathway in HemECs. A, Top 15 Gene Ontology terms enriched in the differentially expressed genes (DEGs) between the PFK15 treatment and control groups. B, Top 15 KEGG pathways enriched in the DEGs between the PFK15 treatment and control groups. C, Top 10 significantly enriched pathways identified by integrated transcriptional and metabolic analysis. D, STRING functional protein associations based on transcriptional data. E, Immunoblot analysis of Akt and PFKFB3. F, PI3K-Akt pathway protein expression after PFKFB3 inhibition by PFK15. G, PI3K-Akt pathway protein expression after PFKFB3 inhibition by shPFKFB3