Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase

Table 1 Summary of NOC2L roles in biological events

NOC2L-associated molecules	Direct effect by NOC2L	Biological events
P53	P53 acetylation↓ → P53 activity↓	Apoptosis inhibition Cell-cycle arrest inhibition
MDM2	P53 ubiquitination↑ → P53 activity↓
Aurora B	P53 phosphorylation↑ →P53 activity↓
P63	P63-occupied histone acetylation↓ → P63-denpendent transcription↓	Apoptosis inhibition Cell-cycle arrest inhibition Cell division dysfunction
RB	RB acetylation↓ → RB activity↓	Breast cancer proliferation
EZH2	EZH2-occupied histone acetylation↓ → FOXO3 transcription↓	Colorectal cancer proliferation

ISSN: 1479-5876