Fig. 7

CHD4 is involved EZH2-mediated regulation of the Wnt/β-catenin pathway. A–F GSEA showed that CHD4 expression was associated with some signalling pathways. G The accumulation of total β-catenin did not change when CHD4 was downregulated. H Overexpression of EZH2 can reverse the inhibition of β-catenin accumulation in the nucleus caused by the downregulation of CHD4. I Diagram of the mechanism by which CHD4 activates the EZH2/β-catenin pathway to promote ovarian cancer invasion and metastasis