Table 1 Overview of the characterization of MUG Lucifer cell lines
From: Targeting epigenetic features in clear cell sarcomas based on patient-derived cell lines
MUG Lucifer prim | MUG Lucifer met | |
|---|---|---|
Growth properties | Semi-adherent, more cells in suspension | Semi-adherent, more adherent cells |
Gene fusion | EWSR1::ATF1 | EWSR1::ATF1 |
CNA profile | Gain in Chr 5, 7, 8, 17 | Gain in Chr 1, 5, 7, 8, 17; loss in Chr 15 |
IHC marker | S100, Sox10, MelanA, HMB45 | S100, Sox10, MelanA, HMB45 |
SACF assay | Bigger and more colonies | Smaller and less colonies |
In vivo tumorigenicity | Lower tumor volume and less blood supply, tumor growth starts on day 28 | Higher tumor volume and more blood supply, tumor growth starts on day 20 |